INS and obesity due to melanocortin 4 receptor deficiency: Unhealthy or dysfunctional adipocytesare part of the obesity phenotype.They are larger, have an impaired glucose uptake and insulin signaling,an elevated inflammatory response, and decreased respiration.34 While we did not investigate the latter characteristics,adipocytes exposed to plastic chemicals were larger and containedmore triglycerides compared to those treated with rosiglitazone (Figure 3).