Significantly (P < 0.05) higher levels of IL‐6 and IL‐8 were observed in the plasma of CC patients compared with individuals with PC and controls. IFN‐γ was significantly higher (P < 0.05) in controls compared with PC patients. The levels of TNF‐α and IL‐10 did not differ between groups. The gene discussed is CXCL8; the disease is pachyonychia congenita.