Pyruvate kinase, PKM2, catalyzes the final and irreversible step of glycolysis to generate pyruvate and ATP.[39] Restricted PKM2 activity is critical to central anabolic metabolism for tumor growth and leukemia initiation.[40, 41]l‐Phe inhibits PKM2 activity and manipulates cellular glucose metabolism.[42] However, the therapeutic impact remains uncovered, potentially due to the lack of efficient delivery approaches. The gene discussed is PKM; the disease is leukemia.