On the other hand, the transcriptional modulation of tissue levels of NFkB, tumor necrosis factor alpha (TNF-α), plasmatic levels of pentraxin-3 as well as lipid peroxidation in rats, are related to the anti-inflammatory and healing effects of ADO in the inflamed colon tissue; so apparently this nucleotide promotes the healing of colon and rectum (in acetic acid-induced acute colitis) through an immunosuppressive effect in the intestinal tissue that contributes to heal ulcerative colitis [31]. The gene discussed is TNF; the disease is ulcerative colitis.