In conclusion, the present study suggested that CXCL12 rs1801157 was significantly related with breast cancer risk, disease stage and ER feature, while CXCL12 rs2297630 or rs2839693 had no association with breast cancer susceptibility or clinicopathological parameters, except for a negative correlation of rs2839693 with PR feature. Here, CXCL12 is linked to breast cancer.