NKX2-1 and empty sella syndrome: Accornero et al. presented a single case of a patient with pituitary stalk duplication and changes in the basal ganglia, caused by a deletion on chromosome 14 harboring TITF1. [35] Salvatore et al. identified features of “empty sella” in two adult patients, whereby the abnormality was more marked in the parent who had longer disease duration [5].