These observations were in line with the well-documented pathophysiology of KIRC that the aberrantly accumulated Hypoxia Inducible Factor 1 (HIF1) induced metabolic shift toward aerobic glycolysis in tumor cells and pro-angiogenic dynamics in the stroma (Cohen and McGovern, 2005) (Gatto et al., 2014). This evidence concerns the gene HIF1A and neoplasm.