APLN and neoplasm: Therefore, given that both the VEGFA and APLN exerted angioplasty effects (Figures 3B and 3C) on the stroma in a paracrine way (Figures 4A and 4B), the hypoxia-related signaling initiated by the aberrantly accumulated HIF1 in the KIRC tumor can be acknowledged as their shared upstream origin (Figure 3A).