In particular, although the tumor suppressor DNA damage–inducible transcript 4 (DDIT4) is induced under stress conditions in normal bone cells to inhibit metabolism activated by the mammalian target of rapamycin (mTOR) in the cytoplasm,(22) MG‐63 osteosarcoma cells exhibit high levels of DDIT4 sequestered to the mitochondria as a potential mechanism to regulate mTOR activation and cancer progression. The gene discussed is DDIT4; the disease is osteosarcoma.