DDIT4 is a known tumor suppressor gene predominantly expressed in the cytoplasm under certain stress conditions to function as a potent mTOR inhibitor.(58) However, recent findings show that DDIT4 is highly expressed in malignant cancers, leading to poor cancer‐related prognosis in a paradoxical manner,(23, 44) suggesting that for certain genes the expression profiles cannot be functionally generalized (Supplemental Fig. S3). The gene discussed is DDIT4; the disease is cancer.