In terms of hypoxia, decreased OXPHOS after 1,25(OH)2D treatment is likely to increase molecular oxygen levels as hypoxia in cancer cells is partly due to increasing O2 consumption and reduction to water that can thereby induce EMT.(29) Hyperoxia is also supported by the increased SOD2 levels after 1,25(OH)2D treatment, as SOD2 metabolizes superoxide radicals into hydrogen peroxide. This evidence concerns the gene SOD2 and cancer.