ESR1 and osteosarcoma: 1,25(OH)2D treatment also may promote estrogen receptor binding, suggesting a synergistic effect to help promote the normal bone‐forming osteoblast phenotype in osteosarcoma cells.(51) Overall, 1,25(OH)2D promotes chromatin accessibility in MG‐63 cancer cells to enhance the regulatory effects of specific TFs that may play important roles in oxidative stress defense and normal tissue and cellular developmental processes.