These observations in Gnas E1+/−p mice directly correlate with the previous findings in the literature suggesting that impaired Gsα signaling leads to an osteopenic bone phenotype.(36, 37, 38, 39, 40, 41) These findings could have potential implications for patients with PPHP and have yet to be correlated. Here, GNAS is linked to pseudopseudohypoparathyroidism.