PAMPs in the root canal system can cause apical periodontitis (inflammation in bone and tissues surrounding the root tips).(11) To examine the consequences of bony inflammation in mice with or without the CBM mutation in SH3BP2, we exposed dental pulp of right mandibular first molars in 6‐week‐old male and female Sh3bp2+/+, Sh3bp2KI/+, and Sh3bp2KI/KI mice and examined right (pulp exposure) and left (no pulp exposure) mandibles at 3, 7, 14, and 42 days after dental drilling (Fig. 1A). Here, SH3BP2 is linked to periapical periodontitis.