Other studies have confirmed that an elevated serum VEGF level following hCG administration can trigger the development of OHSS in women undergoing in vitro fertilization (IVF)12,13, indicating that the serum VEGF level can predict the risk of OHSS and that the odds of developing OHSS may be reduced by inactivating VEGF receptors and inhibiting the VEGF signaling pathway14. This evidence concerns the gene VEGFA and ovarian hyperstimulation syndrome.