In contrast, VEGF mRNA and protein levels were significantly higher in granulosa cells from OHSS patients than in cells from controls (Fig. 1b, c), and VEGF levels were increased twofold in granulosa cells from controls cultured in the presence of hCG for 24 h compared to untreated cells (Fig. 1d, e). This evidence concerns the gene VEGFA and ovarian hyperstimulation syndrome.