ITM2B and Autoimmunity: Recently, Tahir et al. reported that plasma anti-guanine nucleotide-binding protein G(olf) subunit alpha and anti-integral membrane protein 2B antibodies correlated with ICI-induced hypophysitis12, while Kanie et al. reported that serum anti-pituitary antibodies or anti-corticotroph antibodies were associated with the autoimmunity against pituitary hormones or corticotroph13.