Next, we explored relationships between changes in CSF immune, inflammation, and vascular markers, with key study outcomes: (1) CSF markers of AD (Aβ40, Aβ42, Aβ42/40 ratio, total tau, tau-p181, Aβ42/tau ratio), MRI measurements of AD (global WMHV, deep WMHV, hippocampal and entorhinal cortex volume, temporal-parietal meta-region of interest), and performance on cognitive and functional tests (Alzheimer’s Disease Assessment Scale-Cognition version 13/ADAS-Cog13, memory composite, Activities of Daily Living-MCI version/ADL-MCI, Clinical Dementia Rating Scale-Sum of Boxes/CDR-SB). The gene discussed is MAPT; the disease is dementia.