CASP1 and acute kidney injury: We studied CP-induced AKI and its modulation by RA and associated molecular mechanisms and report data on the following aspects: (i) AKI induced by a single injection of CP was investigated, (ii) NLRP3 inflammasome signaling pathway activation was evaluated in CP-induced AKI and (iii) the therapeutic effect of RA, as a caspase-1 inhibitor against CP-induced AKI was examined.