Autoantibody profiling in patients with AD identified various antigenic proteins such as SOS1, TNFRSF21, ATM, S100A1, PTCD2, or FRMD8, which were up-regulated in the blood of patients with AD and showed that the use of autoantibody panels or combinations elevated the possibility of AD diagnosis22,23. The gene discussed is TNFRSF21; the disease is Alzheimer disease.