Integrative analysis of the somatic mutations (nonsynonymous SNVs and indels), CNVs, and SVs revealed several common types of HCC driver-gene alterations, which had comparable numbers in the primary and recurrent tumors, including TP53 mutation, MYC amplification, and TERT amplification or promoter mutation (Fig. 1e). This evidence concerns the gene TP53 and hepatocellular carcinoma.