Integrative analysis of the somatic mutations (nonsynonymous SNVs and indels), CNVs, and SVs revealed several common types of HCC driver-gene alterations, which had comparable numbers in the primary and recurrent tumors, including TP53 mutation, MYC amplification, and TERT amplification or promoter mutation (Fig. 1e). The gene discussed is TERT; the disease is hepatocellular carcinoma.