Importantly, we have also observed induction by PD-L1–CAR T cells of retardation in tumor growth in the models of both MCF-7-pLVX (figure 4E, left-hand panel and online supplemental figure 4J, left-hand panel) and MCF-7-PD-L1 xenografts (figure 4E, right-hand panel and online supplemental figure 4J, right-hand panel), which confirms that PD-L1–CAR can be effective against initially PD-L1 low/null cells in a growing in a living organism. This evidence concerns the gene CD274 and neoplasm.