CD274 and neoplasm: In summary, we demonstrate the efficacy of PD-L1–CAR T/NK/NK-92 cells against a model of triple-negative breast cancer intrinsically expressing high levels of PD-L1.29 Our work corroborates the notion that PD-L1 is an attractive target for prospective CAR-based anticancer therapies and could be applied in a considerable percentage of malignancies of various histopathological types to directly eliminate tumor cells and TME cells expressing PD-L1 on their surface.