The large cohort of well characterised LBD is of particular interest, with biomarker confirmation of the diagnosis through Dopamine Transporter scan (DAT) scan or MIBG in most cases and PET-Aβ scans in half.23 26 30 There were no significant differences when comparing the distribution of biomarkers in PET-Αβ-positive LBD compared with PET-Aβ-negative LBD suggesting the limited potential of these plasma biomarkers to identify coexisting AD pathology in LBD, at least with regard to brain amyloid. Here, PPIB is linked to Alzheimer disease.