Trifunctional NKp46 engager molecules (hereafter referred to as CD19-NKp46-NKCE and CD20-NKp46-NKCE), coengaging CD16A and targeting either CD19 or CD20, have been demonstrated to promote efficient NK cell–mediated antitumor activity in several preclinical models of lymphoma (34). Here, FCGR3A is linked to lymphoma.