Breast cancer (BrCa) is a heterogeneous disease, with genomic profiling studies having identified five major human breast cancer intrinsic subtypes according to PAM50 classification (luminal A, luminal B, HER2-positive, basal-like and normal-like), which differ in their molecular profiles, incidence and prognosis [1]. This evidence concerns the gene ERBB2 and invasive breast carcinoma.