METTL3 and neoplasm: The tumor burden and numbers of tumor foci in lung were also much reduced following either Mettl3 knockout (KPE vs. KPEM−/−) or ALKBH5 overexpression (KPE vs. KPA), and greater effects were observed in the group with both Mettl3 knockout and ALKBH5 upregulation compared with that in mice modulated for either protein alone (KPEM−/− and KPA vs. KPAM−/−, Fig. 2 C-D).