NLRP3 and metabolic dysfunction-associated steatohepatitis: NLRP3 inflammasome was reported to be associated with the histologic severity of NAFLD in patients [7], and NLRP3 plays a crucial role in the pathogenesis of NASH induced by methionine choline-deficient diet (MCD) [8], high-fat diet (HFD) [9], and high fat-cholesterol-sugar diet (HF-HC-HSD) [10, 11].