NLRP3 and metabolic dysfunction-associated steatotic liver disease: In NAFLD, the dysregulated lipid environment in the liver leads to the accumulation of harmful lipids within hepatocytes, which not only causes organelle dysfunction or cellular death but also serves as DAMPs for NLRP3 inflammasome [4, 48], the gut-derived LPS also provides the priming step for NLRP3 inflammasome activation [4].