GCK and type 2 diabetes mellitus: In conclusion oral treatment with Euphorbia helioscopia methanolic extract was able to modulate the carbohydrate metabolic enzymes Pyruvate Kinase, Glucose 6 phosphate dehydrogenase, phosphofructokinase, and glucokinase in serum and can mitigate the oxidative stress and improve the activity of the antioxidant enzymes ultimately reversing the pathogenesis of type 2 diabetes.