In summary, so far as we known, our results first showed that CDK1, TOP2A, CYP2C9, and CYP3A4 genes correlated to curcumin-related chemotherapy of hepatocellular carcinoma, more than just correlated to diagnosis and prognosis of hepatocellular carcinoma which had highlighted by the previous studies [76, 78]. This evidence concerns the gene CYP3A4 and hepatocellular carcinoma.