ACLY and cancer: For example, fatty acid synthase (FASN) was upregulated in multiple cancer types [47] and is correlated with the amplification of HER2 in breast cancer [48]; also, ATP-Citrate Lyase (ACLY) was upregulated in gastric adenocarcinoma [49], and downregulation of ACLY could decrease cell proliferation and invasion in multiple cancer cells [50].