As transmembrane immune signaling adaptor proteins, TYROBP and FCER1G may mediate an intracellular signal via immunoreceptor tyrosine-based activation motif (ITAM) to up-regulate the expression of SPI1 and then initiate the whole SPI1-TYROBP-FCER1G network for a competent immunological surveillance function with upregulated immune infiltrations in tumor microenvironment [60–63]. The gene discussed is FCER1G; the disease is neoplasm.