Furthermore, we extended the top 1 cluster into a more conserved TYROBP co-expression network with 10 hub genes (SPI1, TYROBP, FCER1G, ITGB2, C1QB, C1QA, LY86, LCP2, CCR1, AIF1) by an analysis across cancer types, which was associated with immune cell proliferation and T cell activation. The gene discussed is SPI1; the disease is cancer.