SPI1, as the key transcription factor for the network, may shape a positive-feedback network with the signaling from TYROBP/FCER1G or environmental TNF-α/IFN-γ, then furtherly initiate the whole SPI1-TYROBP-FCER1G network to regulate the immune infiltration and cancer prognosis (Fig. 8C). The gene discussed is TNF; the disease is cancer.