In the BV2 mouse microglial cell line, expression of microglial genes such as Irf8, Runx1, Csf1r, Csf1, Il34, Aif1 (Iba1), Cx3cr1, Trem2 and Tyrobp, some of which already cited in this article as risk factors for AD, were found to be regulated by SPI1 [106]. The gene discussed is TREM2; the disease is Alzheimer disease.