For example, lncRNA HIF1A-AS3 affects the expression of DNMT3a through downregulation of miR-129-5 [20]; the lncRNA-SNHG7/miR-29b/DNMT3a axis affects the activation, autophagy and proliferation of hepatic stellate cells in liver fibrosis [21]. The gene discussed is HIF1A; the disease is Hepatic fibrosis.