Between D4 and D0, significantly enriched KEGG terms for DE mRNAs were primarily involved in ribosomes, proteoglycans in cancer, PPAR signaling pathways, Parkinson’s disease, oxidative phosphorylation, non-alcoholic fatty liver disease, Huntington’s disease, focal adhesion, ECM-receptor interaction, Alzheimer’s disease, glycerolipid metabolism, and citrate cycles (Fig 6A). The gene discussed is PPARA; the disease is early-onset autosomal dominant Alzheimer disease.