Between D8 and D0, significantly enriched KEGG terms for DE mRNAs were primarily involved in terpenoid backbone biosynthesis, systemic lupus erythematosus, steroid biosynthesis, PI3K-Akt signaling pathways, focal adhesion, ECM-receptor interaction, and alcoholism (Fig 7A). The gene discussed is AKT1; the disease is systemic lupus erythematosus.