TNFAIP3 and peritonitis: To exclude the possibility that sterile peritonitis contributes to TNF-independent death in A20/Abin-1T-ΔIECTnf–/– mice, we treated mice with tamoxifen by oral gavage rather than i.p. A higher dose of tamoxifen was required to delete A20 and Abin-1 in IECs from the small intestine and colon by oral gavage (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI154993DS1), and with this approach A20/Abin-1T-ΔIECTnf–/– mice died with similar kinetics to those of A20/Abin-1T-ΔIEC mice (Figure 1A).