Taken together, these results suggest that RH impairs Glut3-mediated glucose uptake by inhibiting the TRPC6/Ca2+/AMPK pathway, which not only leads to dysfunctional neuronal mitochondrial energy metabolism but also eventually accelerates the progression of cognitive deficits in STZ-induced APP/PS1-DM mice (Figure 7L). This evidence concerns the gene TRPC6 and Cognitive impairment.