In this study, we report that GLUT1 expression in the hippocampus of APP/PS1-DM mice is increased by RH, and several studies have revealed that insulin-induced hypoglycemia in diabetic rats increases GLUT1 expression in the BBB, which is essential for maintaining the glucose supply required for neurological functions (41, 42). The gene discussed is SLC2A1; the disease is Hypoglycemia.