In this study, hippocampal GLUT3 expression in APP/PS1-DM mice were significantly higher than that of APP/PS1 mice, even though glucose uptake remained unchanged, indicating that the increase in GLUT3 expression is an adaptive response to diabetes to maintain adequate neuronal glucose supply; however, RH disturbs this adaptation in APP/PS1-DM mice. The gene discussed is SLC2A3; the disease is diabetes mellitus.