To uncover whether hippocampal mitochondrial dysfunction and cognitive deficits caused by RH causally result from the reduction of GLUT3-mediated glucose uptake, we first overexpressed GLUT3 in PC12 cells (Supplemental Figure 7, A and B) using lentiviral vector and found that it led to significantly increased mitochondrial function and ATP content (Supplemental Figure 7, C and D). Here, SLC2A3 is linked to Cognitive impairment.