APP and Cognitive impairment: Here, we extend these observations and link the TRPC6/Ca2+/AMPK pathway and GLUT3 expression in APP/PS1-DM-RH mice, i.e., that RH reduces hippocampal TRPC6/AMPKα/GLUT3 expression but that hyperforin-induced long-term activation of TRPC6 reverses this effect and delays the onset of severe cognitive impairment.