GLUT3 overexpression markedly reduced the levels of Aβ40 and Aβ42 (Supplemental Figure 8B) and levels of proinflammatory cytokines, including TNF-α, IFN-γ, IL-1β, and IL-6 in the DG area of the hippocampus in APP/PS1-DM-RH mice (Supplemental Figure 8C), indicating that GLUT3 overexpression ameliorates RH-induced AD-type pathology. Here, SLC2A3 is linked to Alzheimer disease.