The pancreatic cancer associations were consistent with previously reported RRs of 2-3 and lifetime risks of 1%-4% for BRCA1 carriers3,4,6 and RRs of 3-6 and lifetime risks of 3%-5% for BRCA2 carriers (Data Supplement).2,5-8 Notably, the RR was higher for BRCA2 carriers age < 65 years. Here, BRCA1 is linked to familial pancreatic carcinoma.