Among the suggested associations with other cancers, the association between BRCA1/2 PVs and stomach cancer is under considerable debate.4,5 This study validated and further elucidated this association: there were associations with both BRCA1 and BRCA2 PVs, with RRs of 2.17 (3.50 for age < 65 years) and 3.69, respectively. The gene discussed is BRCA1; the disease is gastric cancer.