BRCA1 and cancer: BRCA1 PVs were associated with male breast (RR = 4.30; 95% CI, 1.09 to 16.96), gallbladder (RR = 3.34; 95% CI, 1.34 to 8.28), pancreatic (RR = 2.36; 95% CI, 1.51 to 3.68), stomach (RR = 2.17; 95% CI, 1.25 to 3.77), and colorectal (RR = 1.48; 95% CI, 1.01 to 2.16) cancers (Table 2).