C4BPA and COVID-19: Finally, a longitudinal analysis of COVID-19 patients during hospitalization revealed that Gal-3BP and other proteins of the innate immune system mediators such as complement factors C2, C9, C4BPA, alpha-1-acid glycoprotein 1 (ORM1) and monocyte differentiation antigen CD14, were upregulated early during hospitalization but decreased at later times [15].