Among the tear proteins deregulated in PD patients, a group of six proteins stood out, five of which that were overexpressed in the PD group relative to the CTs (prelamin A/C—LMNA, cathepsin D—CATD, acid ceramidase—ASAH1, transitional endoplasmic reticulum ATPase—TERA and cytoplasmic dynein 1—DYHC1), whereas one of them was downregulated (tripeptidyl-peptidase 1—TPP1: Table 3). This evidence concerns the gene ASAH1 and Parkinson disease.