We chose the lowest equimolar dose of Chol-siSTAT3 [2 mg/kg] and Chol-DsiSTAT3 [2.5 mg/kg] that provided maximum suppression of STAT3 mRNA levels in primary 4T1 breast tumors (Figure 3A) to minimize possible effects of dose saturation in the primary tumor. Here, STAT3 is linked to neoplasm.