STAT3 and neoplasm: We chose an equimolar dose of Chol-siSTAT3 [0.41 mg/kg] and Chol-DsiSTAT3 [0.5 mg/kg] that does not maximally suppress STAT3 mRNA in primary 4T1 breast tumors (Figure 3A) to eliminate possible effects of tumor dose saturation on the kinetics of mRNA suppression in the primary tumor.