STAT3 and breast neoplasm: We chose the lowest equimolar dose of Chol-siSTAT3 [2 mg/kg] and Chol-DsiSTAT3 [2.5 mg/kg] that provided maximum suppression of STAT3 mRNA levels in primary 4T1 breast tumors (Figure 3A) to minimize possible effects of dose saturation in the primary tumor.