Chol-siSTAT3 polyplexes (Figure 3B, grey circles, dashed line) suppressed STAT3 mRNA copy numbers in primary 4T1 breast tumors to a similar extent as Chol-DsiSTAT3 polyplexes (Figure 3B, grey squares, solid line) at 24 h [11 ± 4 (SD) vs. 10 ± 4%], 48 h [43 ± 4 (SD) vs. 43 ± 5%], 72 h [13 ± 6 (SD) vs. 11 ± 5%], and 96 h [8 ± 8 (SD) vs. 6 ± 10%]. This evidence concerns the gene STAT3 and breast neoplasm.