IGF2R and cancer: The extracellular matrix (ECM) produced by cancer associated fibroblasts (CAF) supports cancer cells expressing α-smooth muscle actin and fibroblast activation protein (FAP), both upregulating the expression of other functional cell surface proteins like platelet-derived growth factor receptor β and the insulin-like growth factor receptor II; activated fibroblasts could benefit from delivery of nanoparticles carrying drugs, especially in liver cancer to downregulate growth factors [95].