INS and Alzheimer disease: 2020). AD is also associated with acetylcholine concentrations and neuroinflammation in the hippocampus (Ferreira-Vieira et al. 2016; Park et al. 2017a). Since the aetiology of AD is multifactorial, drugs limited to one target may not be sufficient to confer protection (Hodson 2018). Herbs contain various components that might prevent and delay disease progression by modulating hippocampal insulin signalling and potentiating insulin sensitivity, especially in the hippocampus, thus preventing and alleviating the progression and symptoms of AD (Chen et al. 2020).