The various STIM‐ORAI combinations lead to varying magnitudes of Ca2+ signals with distinct spatiotemporal features and different kinetics.[1, 3] Aberrant SOCE signaling has been implicated in a growing number of diseases, such as immunodeficiency, cardiovascular disease, diabetes, and cancer.[5] Thus, it is of great importance to explore what STIM‐ORAI combinations form SOC subtypes for each cell type and which ones contribute to Ca2+ entry in health and disease. Here, UBXN11 is linked to cancer.