STIM1 and cancer: For example, STIM1 is reported to interact with hypoxia‐inducible factor‐1 (HIF1) and mediate hypoxia‐driven hepatocarcinogenesis.[8] Clearly, aberrant SOCE is tightly linked to cancer growth, proliferation, migration, and metastasis.[6, 7] Therefore, STIM and ORAI proteins promise to serve as excellent targets for developing anti‐cancer therapeutics.