INS and obesity due to melanocortin 4 receptor deficiency: Primary findings of this study are: (1) the WD promotes obesity and glucose intolerance; (2) CRS improved body weight and body weight gain in both control and WD mice; (3) CRS improved glucose tolerance in WD‐fed animals with no alterations to insulin levels; (4) the WD induced robust changes in exploratory behavior which was lost when the WD was combined with CRS; (5) despite WD+CRS mice exhibiting a more favorable cardiometabolic risk profile than WD‐fed animals, this did not translate into improvements in postischemic myocardial outcomes.