Postischemic inflammation is a hallmark of ischemic stroke pathology that plays a critical role in acute brain damage and has profound implications in long‐term recovery.[53] The inflammatory response is regulated by M1 and M2 polarization of microglia, and the failure of the M1/M2 phenotype balance in inflammation‐associated injury can lead to chronic inflammation and secondary damage.[54] As presented in Figure 7, we observed that our PBM treatment with a 630‐nm wavelength clearly reduced microglia (Iba‐1+) in the ischemic cortex. The gene discussed is AIF1; the disease is ischemic stroke.