Since reduced skin cancer and increased psoriasis are also observed in mice lacking sPLA2-IID, which attenuates Th1/Th17 immunity by mobilizing ω3 fatty acids in lymphatic tissues (31), it is plausible that an altered systemic immunological balance may also underlie the skin phenotypes in Pla2g2a–/– mice. Here, PLA2G2A is linked to skin cancer.