IL17A and Increased total granulocyte count: In the accompanying paper (75), Doré et al. have found that PLA2G2ATGN mice on a C57BL/6 genetic background exhibited age-associated systemic inflammation with lymphomegaly, granulocytosis, elevation of circulating IL-17A, and increased arthritis, due to alteration of the gut microbiota and bacteria-derived lipids.