PLA2G2A and cancer: Some bacterial metabolites such as trigonelline and ectoine, which can modulate inflammation and cancer (56), and dicarboxylic acids such as pimelate, sebacate, and azelate, whose levels are associated with changes in gut microbiota such as Ruminococcaceae (57), were reduced in Pla2g2a–/– mice relative to Pla2g2a+/+ mice (Figure 5D), providing additional insight into the view that sPLA2-IIA contributes to shaping of the intestinal microbiota.