OPTN and ocular melanoma: As expected, through CUT&Tag of SIRT1 in ocular melanomas (https://www.biosino.org/, accession number: OEP002155; Figure S11), we observed a significant promotion of SIRT1 binding to the OPTN promoter in metformin‐treated cells (Figure 6C, lanes 7 and 8, Figure 6D,F and Table S4).