OPTN and ocular melanoma: First, through H3K9Ac Cleavage Under Targets and Tagmentation (CUT&Tag) analysis, we found high histone acetylation level in the OPTN promoter in ocular melanoma cells (MUM2B) compared to normal pigmented cells (PIG1) (https://www.ncbi.nlm.nih.gov/geo/, accession number: GSE162573; Figure 6A).