Unexpectedly, metformin‐treated melanoma cells presented decreased levels of LC3 II/I ratio, Beclin1 and ATG5, and increased p62 in a dose‐dependent (Figure 2A and Figure S2A) and time‐dependent (Figure 2B and Figure S2B) manner, which indicated that metformin acted as an autophagy inhibitor in ocular melanoma cells. The gene discussed is ATG5; the disease is ocular melanoma.