We queried the cBioPortal database (http://www.cbioportal.org/), which provides information of large‐scale cancer genomics, and found that most of the above‐mentioned mutations present in the mutation gene list of combined GBC samples of two previous studies, for instance, TP53 (50%), MUC16 (18.8%), TTN (15.6%), MUC4 (6.3%), CTNNB1 (4.9%), USP29 (3.1%), AKAP6 (3.1%) and DSCAML1 (3.1%).26, 27. The gene discussed is MUC4; the disease is cancer.