For example, the TTN gene was suggested to be a potential oncogene in lung cancer19, 20; MGAT5B was reported to be differentially expressed or epigenetically dysregulated in a variety of cancers21, 22; and AKAP6 mutations were demonstrated to be correlated with the susceptibility and prognosis of several cancers, including glioma, epithelial ovarian and gastric cancer.23, 24, 25. This evidence concerns the gene TTN and central nervous system cancer.