TTN and cancer: For example, the TTN gene was suggested to be a potential oncogene in lung cancer19, 20; MGAT5B was reported to be differentially expressed or epigenetically dysregulated in a variety of cancers21, 22; and AKAP6 mutations were demonstrated to be correlated with the susceptibility and prognosis of several cancers, including glioma, epithelial ovarian and gastric cancer.23, 24, 25