Survival analysis demonstrated that a high CD163+ cell infiltration (4th quartile) in the tumor‐adjacent normal‐like epithelium, but not in the tumor, was significantly associated with shorter survival without metastases (p = .0001) and PCa‐specific mortality (p = .0124, Figure 1B) as well as with CRPC‐free survival (p = .016, Figure S1B). Here, CD163 is linked to posterior cortical atrophy.