Downregulated genes present in the EMT signature were enriched for processes involving early stages of cell development (Fig. 2J), while the downregulated genes in metastasis signature were enriched for response to growth stimulus factors and positive regulation of the ERK1 and ERK2 signaling pathway cascade (Fig. 2K), a known disrupted pathway in human melanoma [35]. Here, MAPK1 is linked to melanoma.