Compared to the Ad and PBS groups, the expression of P21, P53, Bax and Caspase‐3 in the Ad‐ING4, Ad‐OSM and Ad‐ING4‐OSM groups was stronger while the expression of Cox‐2, Bcl‐2 and CD34 was weaker, indicating that ING4 and/or OSM might upregulate P21, P53, Bax and Caspase‐3 expression and downregulate Cox‐2, Bcl‐2 and CD34 expression, respectively, in Hep‐2 cell‐xenografted tumours. Here, TP53 is linked to neoplasm.