Ad‐ING4, Ad‐OSM and Ad‐ING4‐OSM upregulate P21, P53 and Caspase‐3 expression and downregulate Cox‐2, Bcl‐2 and CD34 expression by immunohistochemistry in Hep‐2 cell‐xenografted tumours. Here, TP53 is linked to neoplasm.