Moreover, ING4 downregulates IL‐6, IL‐8, MMP‐2 and MMP‐9 expression in the human lung adenocarcinoma cell line A54925 and inhibits tumour cell growth and induces cell cycle alteration and apoptosis in various tumour types,6, 21, 25, 26, 27, 28, 29 such as hepatocellular, melanoma, colorectal, glioblastoma, breast and lung cancer. The gene discussed is MMP9; the disease is melanoma.