ZYX and Hypertension: Therefore, the aim of this work was to study the consequences of the global genetic loss of zyxin for cardiac function in two different mouse models of experimentally induced hypertension, the deoxycorticosterone acetate (DOCA) /high-salt (DOCA-salt) induced hypervolemia and the chronic exposure to angiotensin (Ang) II induced model of hypertension [17].