Clinical trials of anti-PD-1 antibodies combined with TKI, including sorafenib (NCT03211416, NCT03439891, NCT02988440), regorafenib (NCT03347292), cabozantinib (NCT03299946 and NCT01658878), and axitinib (NCT03289533), have shown that, compared with monotherapy with TKI, combination therapy could provide more survival benefits in patients with advanced HCC. The gene discussed is PDCD1; the disease is hepatocellular carcinoma.