The results showed that cytokines/chemokines such as IL-8, IL-15, IL-6, IL-7, IL-1β, Eotaxin-3, IL-10, IL-4, MIP-1β, IL-12p70 and VEGF were associated with global tissue injury profile, i.e., ncfDNA, in SOTRs with COVID-19, whereas TNF-β, TNF-α, IL-18, IL-6, IL-13, IL-2Ra, MCP-2, and IL-10 were associated with global tissue injury in Non-SOT patients. The gene discussed is IL4; the disease is COVID-19.