We constructed ceRNA networks in the prostate cancer microenvironment and identified lncRNA LINC01082, miRNA hsa-miR-133a-3p, and genes TTLL12, PTGDS, GAS6, CYP27A1, PKP3, and ZG16B as the potential biomarkers to predict prognosis for prostate cancer. This evidence concerns the gene PKP3 and Familial prostate cancer.