HMGA2 and Familial prostate cancer: For example, NEAT1 can regulate the epigenetics of target gene promoters to play the role of oncogenes, by increasing ACSL4 via sponging miR-34a-5p and miR-204-5p, or HMGA2 via sponging miR-98-5p, and was found significantly associated with prostate cancer prognosis [23, 24].